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AIDS research pioneer Barton Haynes, MD, director of the Duke Human Vaccine Institute, calls the findings "very important."
The AIDS virus would have a much harder time getting around drugs that target the human proteins it needs. On the other hand, drugs that attack human proteins could do harm if the proteins turn out to be crucial to humans, too.
only 15 proteins. In order to replicate to make new copies of itself the virus has to take over the complex machinery of human immune cells. The new findings give scientists a vastly closer look at how HIV pulls off this coup.
"We found dozens and dozens of new things not implicated before in HIV replication," Harvard and Massachusetts General Hospital researcher Stephen J. Elledge, PhD, tells WebMD. scientists Andrew Fire, PhD, and Craig Mello, PhD. The technique allowed Elledge and colleagues to eliminate, one by one, 21,000 proteins in a human cell line. By infecting each of these cell lines with HIV, the researchers were able to see whether a protein was Nike Sb Jacket Camo
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With the exception of a single new agent, all existing HIV drugs target proteins made by HIV itself. Because HIV mutates rapidly, it eventually develops resistance to these drugs by slightly changing its proteins.
"This study uses new technology to come up with questions we really didn't know how to ask. And it points to areas and systems in the host cells we weren't aware were important," Haynes tells WebMD.
Only 36 of these proteins were previously known to interact with HIV, the virus that causes AIDS. The finding is thus a mind boggling expansion of what science knows about the virus. It also offers more than 200 new targets for future anti HIV drugs.
an "HIV dependency factor" something HIV absolutely must have in order to survive in the human body.
HIV itself makes Nike Red Tech Fleece Hoodie
Experts Say Finding Is Major AdvanceJanet Young, PhD, a program officer in the AIDS division of the National Institute for Allergy and Infectious Diseases, says the findings are a big step forward.
"This is one of the first explosions of information people will get from this technique," Elledge says.
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"On Nike Long Sleeve Fleece Hoodie first glance at this, my first thought was, 'What will we do with all these proteins they identified?" Young tells WebMD. "But the key thing is we now have a clearer understanding of how HIV infects cells and causes disease. We can now home in on many of the proteins involved. The potential for developing therapeutics is exciting."
273 New Possible Targets for HIV Drugs
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